This article is devoted to modern approaches in HER-2-positive metastatic breast cancer therapy. Recently treatment algorithm for this type of cancer included trastuzumab plus cytostatic in first line. continuation of trastuzumab with another chemotherapy regimen in second line. further switch to lapatinib and eventual return to trastuzumab after progression. https://parisnaturalfoodes.shop/product-category/shea-butter-lotion-unscented/